Revisión de las implicaciones ocupacionales por exposición al plomo.

  • Nerlis Paola Pájaro Castro Grupo de Investigación GIMCEAD.
  • Wilson Maldonado Rojas Grupo de Investigación GIMCEAD
  • Narcisa Esther Pérez Gari Centro para la Industria Petroquímica, SENA-Regional Bolívar.
  • Jhon Albeiro Díaz Cuadro Grupo de Investigación GIMCEAD.
Palabras clave: Plomo, implicaciones ocupacionales, límites permisibles, mecanismo de acción.

Resumen

El plomo, considerado uno de los metales tóxicos más comunes en el medio ambiente, es frecuentemente utilizado en el mundo para la fabricación de armas, baterías y aditivos para la gasolina, entre otras aplicaciones. La exposición cró- nica a este contaminante es un problema de salud pública que afecta sistemas importantes como el nervioso, el reproductivo y el circulatorio. En varios países la búsqueda de materiales que reemplacen el plomo ha sido implementada con buenos resultados. En Colombia no existen regulaciones nacionales concretas que garanticen el desempeño ocupacional en ambientes libres de plomo, por lo que se hace necesaria la creación de regulaciones que permitan minimizar el riesgo de exposición a este metal tóxico.

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Biografía del autor/a

Nerlis Paola Pájaro Castro, Grupo de Investigación GIMCEAD.
Colombiana, Química Farmacéutica. Magís- ter en Ciencias Farmacéuticas. Universidad de Cartagena, Colombia, Investigadora Grupo de  Investigación GIMCEAD.
Wilson Maldonado Rojas, Grupo de Investigación GIMCEAD
Colombiano, Químico. Magíster en Quími- ca. Universidad de Cartagena, Colombia.  Investigador Grupo de Investigación GIMCEAD.
Narcisa Esther Pérez Gari, Centro para la Industria Petroquímica, SENA-Regional Bolívar.
Colombiana, Administradora en Salud, especialista en Salud Ocupacional. Instruc- tora Centro para la Industria Petroquímica, SENA-Regional Bolívar.
Jhon Albeiro Díaz Cuadro, Grupo de Investigación GIMCEAD.
Máster en Ingeniería y Tecnología Ambiental. Doctorando en Ciencias de la Educación. Director Grupo de Investigación GIMCEAD. Instructor Centro para la Industria Petroquímica, SENA-Regional Bolívar.

Referencias

Adegbesan, BO. and Adenuga, GA. Effect of lead exposure onliver lipid peroxidative and antioxidant defense systems of protein-undernourished rats. In: Biol. Trace Elem. Res. 116 (2007) pp. 219-225.

https://doi.org/10.1007/BF02685932

Ademuyiwa, O., Agarwal, R., Chandra, R. and BEHARI. JR. Effects of sub-chronic low-level lead exposure on the homeostasis of copper and zinc in rat tissues. In: J. Trace Elem. Med. Biol. 24 (2010) pp. 207-211.

https://doi.org/10.1016/j.jtemb.2010.01.002

ATSDR. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Lead. Atlanta, Georgia, USA: ATSDR, 2007.

Aygun, O., Yarsan, E. and Akkaya, R. Lead and copper levels in muscle meat of Crucian carp (Carassius carassius, L. 1758) from Yarseli Dam Lake, Turkey. In: Bull. Environ. Contam. Toxicol. 72 (2004) pp. 135-140.

https://doi.org/10.1007/s00128-003-0251-6

BASHA, D., REDDY, N., RANI, M. and REDDY, M. Age related changes in aminergic system and behavior following lead exposure: Protection with essential metal supplements. In: Neuroscience Research. doi.org/10.1016/j.neures.2013.09.007.

Chinni, S., Khan, R.N. and Yallapragada, P.R. Larval growth in post larvae Penaeus indicus on exposure to lead. In: Bull. Environ. Contam. Toxicol. 67 (2001) pp. 27-34.

CORFITZEN, CB. and ALBRECHTSEN, HJ. Sampling for drinking water quality in drinking water installations regarding metal concentrations – methoddescription and validation of method. Technical University of Denmark. 2008. Disponible en http://www2.blst.dk/udgiv/Publications/978-87-92256-51-5/pdf/978-87-92256-53-9.pdf

DIRILGEN. N. Mercury and lead: Assessing the toxic effects on growth and metal accumulation by Lemna mino. Ecotoxicology. In: Environ. Safety, 74, 2011, pp. 48-54.

https://doi.org/10.1016/j.ecoenv.2010.09.014

DOREA, JG. Mercury and lead during breast-feeding. In: Br J Nutr. 92 (2004) pp. 21-40. ISSN 1475-2662.

DURSUN, N.; ARIFOGLU, C. and SÜER, C. Blood pressure relationship to nitric oxide, lipid peroxidation, renal function, and renal blood flow in rats exposed to low lead levels. In: Biol. Trace Elem. Res. 104 (2005) pp. 141-149. ISSN 1559-0720.

Evans, M.; Fored, C. M., Nise, G., Bellocco, R., Nyrén, O. and ELINDER, CG. Occupational Lead Exposure and Severe CKD: A Population-Based Case-Control and Prospective Observational Cohort Study in Sweden. In: Am. J. Kidney Dis. 55 (2010) pp. 497-506.

https://doi.org/10.1053/j.ajkd.2009.11.012

Fraser, M., Surette, C. and Vaillancourt, C. Spatial and temporal distribution of heavy metal concentrations in mussels (Mytilus edulis) from the Baie des Chaleurs, New Brunswick, Canada. Mar. In: Pollut. Bull. 62 (2011) pp. 1345-1351.

https://doi.org/10.1016/j.marpolbul.2011.03.036

FRASER, S.; MUCKLE, G. and DESPRÉS, C. The relationship between lead exposure, motor. In: Neurotoxicol Teratol. 28 (2006) pp. 18-27. ISSN 0892-0362.

García-Lestón, J.; Méndez, J., Pásaro, E. y Laffon, B. Genotoxic effects of lead: An updated review. In: Environ. Int. 36 (2010) pp. 623-636.

https://doi.org/10.1016/j.envint.2010.04.011

GONZÁLEZ B, D. y ROJAS F, W. Relación entre la exposición crónica ocupacional al plomo y los efectos neurocomportamentales - Revisión documental. Bogotá D.C. 2008. [En línea] Trabajo de grado (Especialista en Salud Ocupacional). Pontificia Universidad Javeriana. Facultad de Enfermería Facultad de Medicina. Disponible en http://www.javeriana.edu.co/biblos/tesis/enfermeria/tesis36.pdf

Hambach, R.; Lison, D.; D'Haese, P.C.; Weyler, J., De Graef, E.; De Schryver, A.; Lamberts, L.V.; Van Sprundel M. Co-exposure to lead increases the renal response to low levels of cadmium in metallurgy workers. In: Toxicology Letters 222(2) (2013) pp. 233-238.

https://doi.org/10.1016/j.toxlet.2013.06.218

Hernández-Ochoa, I.; García-Vargas, G.; López-Carrillo, L.; Rubio-Andrade, M.; Morán-Martínez, J.; Cebrián, M.; Quintanilla-Vega B. Low lead environmental exposure alters semen quality and sperm chromatin condensation in northern Mexico. In: Reproductive Toxicology. 20(2) (2005) pp. 221-228.

https://doi.org/10.1016/j.reprotox.2005.01.007

Kaczmarek-Wdowiak, B.; Andrzejak, R. and Skoczynska, A. The effect of chronic exposure to lead and cadmium on lipid peroxidation in the rat brain. In: Med. Pr. 55, (2004) pp. 403-410.

Kasperczyk, S.; Birkner, E. and Kasperczyk, A. Lipids, lipid peroxidation and 7-ketocholesterol in workers exposed to lead. In: Hum. Exp. Toxicol. 24 (2005) pp. 287-295.

https://doi.org/10.1191/0960327105ht528oa

Kelada, S.N.; Shelton, E. and Kaufmann, R.B. Delta-aminolevulinic acid dehydratase genotype and lead toxicity: a HuGE review. In: Am. J. Epidemiol. 154 (2001) pp. 1-13.

https://doi.org/10.1093/aje/154.1.1

KRISHNA, AK.; SATYANARAYANAN, M. and GOVIL, PK. Assessment of heavy metal pollution in water using multivariate statistical techniques in an industrial area: A case study from Patancheru, Medak District, Andhra Pradesh, India. In: J. Hazard. Mater. 167 (2009) pp. 366-373.

https://doi.org/10.1016/j.jhazmat.2008.12.131

LANPHEAR, BP.; DIETRICH, KN., and BERGER, O. Prevention of Lead Toxicity in US Children. In: Ambul. Pediatr. 3(1) (2003) pp. 27-36. ISSN 1530-1567.

LASLEY, SM.; GREEN, MC. and GILBERT, ME. Rathippocampal NMDA receptorbinding as a function of chronic lead exposure leve. In: Neurotoxicol. Teratol. 23 (2001) pp. 185-189.

https://doi.org/10.1016/S0892-0362(01)00116-7

LASSEN, C.; CHRISTENSEN, CL. and SKÅRUP, S. Masses trøms analyse forbly 2000. DanishEPA, Environmental Project, 789.2003. [On-line] Available at http://www2.mst.dk/Udgiv/publikationer/2003/87-7972-550-3/pdf/87-7972-551-1.pdf

LERET, ML.; GARCIA-UCEDA, F. and ANTONIO, MT. Effects of maternal lead administration on monoaminergic, GABAergic and glutamatergic systems. In: Res. Bull. 58 (2002) pp.469-473.

LI, C., XU, M.; WANG, S.; YANG, X.; ZHOUD, S.; ZHANG, J. LIU, Q. SUN, Y. Lead exposure suppressed ALAD transcription by increasing methylation level of the promoter CpG islands. In: Toxicology Letters. doi:10.1016/j.toxlet.2011.03.002. 2011.

https://doi.org/10.1016/j.toxlet.2011.03.002

LIKHOLAT, EA.; ANAN'EVA, TV. and ANTONIUK, SV. Lipidperoxidation in the lungs upon inhalation exposure to low concentrations of lead salts. In: Ukr. Biokhim. Zh. 72 (2000) pp. 68-71.

Maharachpong, N.; Geater, A. and CHONGSUVIVAT- WONG, V. Environmental and childhood lead contamination in the proximity of boat-repair yards in southern Thailand—I: Pattern and factors related to soil and household dust lead levels. In: Environmental Research. 101(3) (2006) pp. 294-303.

https://doi.org/10.1016/j.envres.2005.12.012

Matte, T. Efectos del plomo en la salud de la ni-ez. En: Salud Pública de México. 45(2), (2003) pp. S200-S224.

MISHRA, KP.; SINGH, V.K.; RANI, R.; YADAV, V.S.; CHANDRAN, V., SRIVASTAVA, S.P., SETH, P.K. Effect of lead exposure on the immune response of some occupationally exposed individuals. In: Toxicol. 188 (2003) pp. 251-259.

MOREIRA, E.; VASSILIEFF, I. and VASSILIEFF, V. Developmental lead exposure: behavioral alterations in the short and long term. In: Neurotoxicol Teratol. 23 (2001) pp. 489-495. ISSN 0892-0362.

NEEDLEMAN, H. L., McFARLAND, C.; NESS, R. B.; FIENBERG, S. E. and TOBIN, M. J. Bone lead levels in adjudicated delinquents. A case control study. In: Neurotoxicol Teratol. 24 (2002) pp. 711-717. ISSN 0892-0362.

Nevin, R. How lead exposure relates to temporal changes in IQ, violentcrime, and unwed pregnancy. In: Environ. Res. 83 (2000) pp. 1-22.

https://doi.org/10.1006/enrs.1999.4045

NORDIC COUNCIL OF MINISTERS. Lead Review. 2003. [Online]. Available at http://www.who.int/ifcs/documents/forums/forum5/nmr_lead.pdf

OLIVERO, J., DUARTE, D., ECHENIQUE, M., GUETTE, J., JOHNSON-RESTREPO, B. and PARSONS, P. Blood lead levels in children aged 5–9 years living Cartagena, Colombia. In: Sci. Total Environ 372 (2010) pp. 707-716. ISSN: 0048-9697.

Paoliello, MM. and De CAPITANI, EM. Occupational and environmental human lead exposure in Brazil". In: Environ. Res. 103 (2007) pp. 288-297.

https://doi.org/10.1016/j.envres.2006.06.013

Patrick, L. Lead toxicity, a review of the literature. Part I: exposure, evaluation and treatment. In: Altern. Med. Rev.11 (2006) pp. 2-22.

PÉREZ-LÓPEZ, R.; NIETO, JM., LÓPEZ-CASCAJOSA, MJ., DÍAZ-BLANCO, M.J., SARMIENTO, A.M., OLIVEIRA V., SÁNCHEZ-RODAS, D. Evaluation of heavy metals and arsenic speciation discharged by the industrial activity on the Tinto-Odiel estuary, SW Spain. In: Mar. Pollut. Bull. 62, (2011) pp. 405-411.

PIZZOL, M., THOMSEN, M. and SKOU ANDERSEN, M. Longterm human exposureto lead from different media and in take pathways. In: Sci Total Environ. 408 (2010) pp. 5478-5488. ISSN: 0048-9697.

PORĘBA, R., GAĆ, P.; PORĘBA, M. and ANDRZEJAK, R. Environmental and occupational exposure to lead as apotential risk factor for cardiovascular disease. In: Environ. Toxicol. Pharm. 31 (2011) pp. 267-277. ISSN: 1382-6689.

Poręba, R., Gać, P., Poręba M. and ANDRZEJAK. R. The relationship between occupational exposure to lead and manifestation of cardiovascular complications in persons with arterial hypertension. In: Toxicol. Appl. Pharmacol. 249 (2010) pp. 41-46.

https://doi.org/10.1016/j.taap.2010.08.012

PROGRAMA DE NACIONES UNIDAS PARA EL MEDIO AMBIENTE. PNUMA 2010. [En línea] Disponible en http://www.unep.org/hazardoussubstances/Portals/9/Lead_Cadmium/docs/Trade_Reports/LAC/Trade_report_LAC_Spanish_and_English.pdf

Ris, M. D., Dietrich, K. N. SUCCOP, P. A., BERGER, O.G. and BORNSCHEIN, RL. Early exposure to lead and neuropsychological outcome in adolescence. In: J. Int. Neuropsy. Chol. Soc. 10 (2004) pp. 261-270.

https://doi.org/10.1017/S1355617704102154

Roberts, H. Changing patterns in global lead supply and demand. In: J. Power Sources. 116 (1-2) (2003) pp. 23-31.

https://doi.org/10.1016/S0378-7753(02)00701-2

Roma-Torres, J. SILVA, S., COSTA, C., COELHO, P., HENRIQUES, MA., TEIXEIRA JP., MAYAN, O. Lead exposure of children and newborns in Porto, Portugal. In: Int. J. Hyg. Environ. Health. 210 (2007) pp. 411-414.

https://doi.org/10.1016/j.ijheh.2007.01.009

Scinicariello, F. MURRAY, HE. and MOFFETT, DB. Lead and delta-aminolevulinic acid dehydratase polymorphism: where does it lead? A meta-analysis. In: Environ. Health Perspect. 115 (2007) pp. 35-41.

https://doi.org/10.1289/ehp.9448

Schneider, J.S. KIDD and S.K. ANDERSON D.W. Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus. In: Toxicology Letters 217(1) (2013) pp. 75-81.

https://doi.org/10.1016/j.toxlet.2012.12.004

Sidhu, P. and Nehru, B. Relationship between lead-induced biochemical and behavioral changes with trace element concentrations in rat brain. In: Biol. Trace Elem. Res. 92 (2003) pp. 245-256.

https://doi.org/10.1385/BTER:92:3:245

Silbergeld, E.K. Facilitative mechanisms of lead as acarcinogen. In: Mutat. Res. 533 (2003) pp. 121-133.

https://doi.org/10.1016/j.mrfmmm.2003.07.010

Skoczyńska, A., Gruber, K. and Belowska-Bien, K. Risk of cardiovascular diseases in lead-exposed workers of crystalglassworks, part I. Effect of lead on blood pressure and lipidmetabolism". In: Med. Pr. 58 (2007) pp. 475-483.

Spivey, A. The weight of lead. Effects add up in adults. In: Environ Health Perspect. 115 (2007) pp. A31-A36.

https://doi.org/10.1289/ehp.1151c31a

Stojek, E. and Skoczyńska, A. Lead effect on vascular endothelium. In: Med. Pr. 54 (2003) pp. 87-93.

Taylor, M. P.; Camenzuli, D.; Kristensen, L. J.; Forbes, M. and Zahran, S. Environmental lead exposure risks associated with children's outdoor playgrounds. In: Environmental Pollution, 178 (2013) pp. 447-454.

https://doi.org/10.1016/j.envpol.2013.03.054

TÉLLEZ, J. y BAUTISTA, M. Exposición ocupacional a plomo: aspectos toxicológicos. Avances de enfermería. XXIII (1) (2005) pp. 31-44.

Trzcinka-Ochocka, M., Jakubowski, M. and Nowak, U. Effectiveness of preventive actions for lead exposed workers:an assessment based on biological monitoring. In: Med. Pr.57 (2006) pp. 537-542.

Valko, M. MORRIS, H. and CRONIN, M.T. Metals, toxicity and oxidative stress. In: Curr. Med. Chem. 12 (2005) pp. 1161-1208.

https://doi.org/10.2174/0929867053764635

Wang, Q., Zhao, HH., Chen, JW., Hao, QL., Gu, KD., Zhu, Y.X., Zhou, YK., YE. Lx. δ-Aminolevulinic acid dehydratase activity, urinary δ-aminolevulinic acid concentration and zinc protoporphyrin level among people with low level of lead exposure. In: Int. J.Hyg. Environ. Health, 213 (2010) pp. 52-58.

https://doi.org/10.1016/j.ijheh.2009.08.003

Watt, G.C.M.; Britton, A.; Gilmour, H.G.; Moore, M.R., Murray, G.D. and Robertson S. J. Public health implications of new guidelines for lead in drinking water: a case study in an area with historically high water lead levels. In: Food and Chemical Toxicology. 38 (1) (2000) pp. S73-S79.

https://doi.org/10.1016/S0278-6915(99)00137-4

Yucra, S., Gasco, M., Rubio, J. y González, G. Exposición ocupacional a plomo y pesticidas órganofosforados: efecto sobre la salud reproductiva masculina. En: Rev. Perú Med. Exp. Salud Pública. 25(4) (2008) pp. 394-402.

Zawadzki, M., Poreba, R. and Gać, P. Mechanisms and toxic effects of lead on the cardiovascular system. In: Med. Pr. 57 (2006) pp. 543-549.

Zhang, Y.M., Liu, X.Z. and Lu, H. Lipid peroxidation andultrastructural modifications in brain after perinatal exposureto lead and/or cadmium in rat pups. In: Biomed. Environ. Sci. 22 (2009) pp. 423-429.

https://doi.org/10.1016/S0895-3988(10)60021-9

Zheng, G.; Tian, L.; Liang, Y., Broberg, K.; Lei, L., Guo, W., Nilsson, J., Bergdahl, IA., Skerfving, S., Jin, T. δ-Aminolevulinic acid dehydratase genotype predicts toxic effects of lead on workers' peripheral nervous system. In: NeuroToxicology, 32 (2011) pp. 374-382.

https://doi.org/10.1016/j.neuro.2011.03.006

Zizza, M.; Giusi, G.; Crudo, M.; Canonaco, M. and Facciolo R. Lead-induced urodegenerative events and abnormal behaviors occur via ORXRergic/GABAARergic mechanisms in a marine teleost. In: Aquatic Toxicology. 126(15) (2013) pp. 231-241.

https://doi.org/10.1016/j.aquatox.2012.11.011

Publicado
2013-12-29
Cómo citar
Pájaro Castro, N. P., Maldonado Rojas, W., Pérez Gari, N. E., & Díaz Cuadro, J. A. (2013). Revisión de las implicaciones ocupacionales por exposición al plomo. Informador Técnico, 77(2). https://doi.org/10.23850/22565035.58
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Artículo de Revisión