Abstract
Strawberry fruit (Fragaria x ananassa) is a widely consumed food worldwide and has been characterized to have a wide range of beneficial properties for human health, mostly associated with its antioxidant potential. The search for bioactive phytochemicals in strawberry has focused mainly on the fruit, while the biochemical profile of the leaves has been little studied and continues to be underutilized, despite being a potential source of bioactive metabolites that could be used in the formulation of food, industrial and pharmaceutical products. In addition, higher bioactive polyphenol content has been reported in strawberry leaves than in the fruit, and strawberry leaves could also be an important source of ellagic acid, a bioactive antioxidant compound, which is limited in the human diet but has great biomedical potential. This literature review aims to evaluate the information available on the characteristics of strawberry crops (Fragaria x ananassa) in Costa Rica, targeting towards the comprehensive use of the agro-industrial residues of this plant. The information reviewed confirmed that the commercialization of strawberry cultivation focuses on the fruit, while the leaves and the rest of the plant's vegetative material are discarded periodically, but could be incorporated into new production chains. Such strategies are especially important for small developing countries with agricultural-based economies, to improve the use of agro-industrial waste and provide added value to crops, aiding both the environment and human health.
References
Aaby, K., Mazur, S., Nes, A., y Skrede, G. (2012). Phenolic compounds in strawberry (Fragaria x ananassa Duch.) fruits: Composition in 27 cultivars and changes during ripening. Food Chemistry, 1 (1), 132, 86–97. https://doi.org/10.1016/j.foodchem.2011.10.037
Afrin, S., Gasparrini, M., Forbes-Hernandez, T. Y., Reboredo-Rodriguez, P., Mezzetti, B., Varela-López, A., … Battino, M. (2016). Promising Health Benefits of the Strawberry: A Focus on Clinical Studies. Journal of Agricultural and Food Chemistry, 64, 4435–4449. https://doi.org/10.1021/acs.jafc.6b00857
Al-Deen, A. T., Al-Naqeb, G., y Al-Maqtari, Q. (2013). Investigation of antioxidant and antibacterial effects of Dodonaea viscose, Fragaria x ananassa duch and Vernonia amygdalina leaves. Aden University Journal, 17 (1), 1–14.
Barquero, J., Meneses, R., Barrantes, L., Ugalde, P., Villalobos, N., y Serrano, D. (2007). Agrocadena de Fresa. Ministerio de Agricultura y Ganadería de Costa Rica. http://www.mag.go.cr/bibliotecavirtual/a00070.pdf
Basu, A., Nguyen, A., Betts, N. M., y Lyons, T. J. (2014). Strawberry As a Functional Food : An Evidence-Based Review Strawberry As a Functional Food : Critical Reviews in Food Science and Nutrition, 54(6), 790–806. https://doi.org/10.1080/10408398.2011.608174
Cádiz-Gurrea, M. de la L., Villegas-Aguilar, M. del C., Leyva-Jiménez, F. J., Pimentel-Moral, S., Fernández-Ochoa, Á., Alañón, M. E., y Segura-Carretero, A. (2020). Revalorization of bioactive compounds from tropical fruit by-products and industrial applications by means of sustainable approaches. Food Research International, 138 (Part B), 109786. https://doi.org/10.1016/j.foodres.2020.109786
Cardoso, O., Donato, M. M., Luxo, C., Almeida, N., Liberal, J., Figueirinha, A., y Batista, M. T. (2018). Anti-Helicobacter pylori potential of Agrimonia eupatoria L. and Fragaria vesca. Journal of Functional Foods, 44, 299–303. https://doi.org/10.1016/j.jff.2018.03.027
Carvalho, S. F. de, Correa, A. P. A., Ferreira, L. V., Vizzotto, M., y Antunes, L. E. C. (2021). Production, chemical components, and content of bioactive compounds of strawberry cultivars. Revista Engenharia Na Agricultura, 29, 275–285. https://doi.org/10.13083/reveng.v29i1.10883
Chaves, V. C., Calvete, E., y Reginatto, F. H. (2017). Quality properties and antioxidant activity of seven strawberry (Fragaria x ananassa duch) cultivars. Scientia Horticulturae, 225, 293–298. https://doi.org/10.1016/j.scienta.2017.07.013
Cordenunsi, B. R., Nascimento, J. R. O., y Lajolo, F. M. (2003). Physico-chemical changes related to quality of five strawberry fruit cultivars during cool-storage. Food Chemistry, 83 (2), 167–173. https://doi.org/10.1016/S0308-8146(03)00059-1
Cubero-Cardoso, J., Serrano, A., Trujillo-Reyes, Á., Villa-Gómez, D. K., Borja, R., y Fermoso, F. G. (2020). Valorization Options of Strawberry Extrudate Agro-Waste. A Review. En Novo de Barros, A. y Gouvinhas, I. (Eds.). Innovation in the Food Sector Through the Valorization of Food and Agro-Food By-Products. IntechOpen. https://doi.org/10.5772/intechopen.93997
Cvetković, D. J., Stanojević, L. P., Stanković, M. Z., Cakić, M. D., Savić, S. R., y Miljković, M. D. (2017). Antioxidant activity of strawberry (Fragaria × ananassa Duch.) leaves. Separation Science and Technology, 52 (6), 1039–1051. https://doi.org/10.1080/01496395.2017.1281305
da Silva, P. M., Lajolo, F. M., y Genovese, M. I. (2008). Bioactive compounds and quantification of total ellagic acid in strawberries (Fragaria x ananassa Duch.). Food Chemistry, 107, 1629–1635. https://doi.org/10.1016/j.foodchem.2007.10.038
Demchak, K. (2013). The Mid-Atlantic Berry Guide for Commercial Growers 2013-2014. The Pennsylvania State University. University Park, PA, USA. http://pubs.cas.psu.edu/freepubs/pdfs/AGRS097.pdf.
El-Hawary, S. S., Mohammed, R., El-Din, M. E., Hassan, H. M., Ali, Z. Y., Rateb, M. E., … El Nagar, El M. B., Othman, E. M., y Abdelmohsen, U. R. (2021). Comparative phytochemical analysis of five Egyptian strawberry cultivars (Fragaria × ananassa Duch.) and antidiabetic potential of Festival and Red Merlin cultivars. RSC Advances, 11, 16755–16767. https://doi.org/10.1039/d0ra10748d
Fait, A., Hanhineva, K., Beleggia, R., Dai, N., Rogachev, I., Nikiforova, V. J., Fernie, A., y Aharoni, A. (2008). Reconfiguration of the achene and receptacle metabolic networks during strawberry fruit development. Plant Physiology, 148, 730–750. https://doi.org/10.1104/pp.108.120691
Ferlemi, A. V., y Lamari, F. N. (2016). Berry leaves: An alternative source of bioactive natural products of nutritional and medicinal value. Antioxidants, 5 (2), 2-10. https://doi.org/10.3390/antiox5020017
Fierascu, R. C., Temocico, G., Fierascu, I., Ortan, A., y Babeanu, N. E. (2020). Fragaria genus: Chemical composition and biological activities. Molecules, 25, 498. https://doi.org/10.3390/molecules25030498
Forbes-Hernandez, T. Y., Gasparrini, M., Afrin, S., Bompadre, S., Mezzetti, B., Quiles, J. L., Giampieri, F. y Battino, M. (2016). The Healthy Effects of Strawberry Polyphenols: Which Strategy behind Antioxidant Capacity?. Critical Reviews in Food Science and Nutrition, 56 (1), S46–S59. https://doi.org/10.1080/10408398.2015.1051919
Fraga, C. G., Croft, K. D., Kennedy, D. O., y Tomás-Barberán, F. A. (2019). The effects of polyphenols and other bioactives on human health. Food and Function, 10 (2), 514–528. https://doi.org/10.1039/c8fo01997e
Giampieri, F., Forbes-Hernandez, T. Y., Gasparrini, M., Afrin, S., Cianciosi, D., Reboredo-Rodriguez, P., Valera-López, A., Quiles, J. L., Mezzetti, B., y Battino, M. (2017). The healthy effects of strawberry bioactive compounds on molecular pathways related to chronic diseases. Annals of the New York Academy of Sciences, Phytochemicals in Medicine and Food, 1–10. https://doi.org/10.1111/nyas.13373
Giampieri, F., Forbes-Hernandez, T. Y., Gasparrini, M., Alvarez-Suarez, J. M., Afrin, S., Bompadre, S., Quiles, J. L., Mezzetti, B., y Battino, M. (2015). Strawberry as a health promoter: An evidence based review. Food and Function, 6, 1386–1398. https://doi.org/10.1039/c5fo00147a
Golovinskaia, O., y Wang, C. K. (2021). Review of functional and pharmacological activities of berries. Molecules, 26, 3904. https://doi.org/10.3390/molecules26133904
Husain, A. M., Mercado, J. A., Teixeira, J. A. da S., y Schaart, J. G. (2011). Review of Factors Affecting Organogenesis, Somatic Embryogenesis and Agrobacterium tumefaciens- Mediated Transformation of Strawberry. Genes, Genomes and Genomics 5 (1), 1–11. https://digital.csic.es/handle/10261/57836
Imran, S. M., Saxena, D., Kazimi, R., y Pratap, S. (2022). Effects of various growing media , as well as jeevamrit , on the growth and production of strawberry : A review. The Pharma Innovation Journal, 11 (4), 405–410. https://www.thepharmajournal.com
Instituto Interamericano de Cooperación para la Agricultura [IICA]. (2017). Manual de buenas prácticas agrícolas y de producción para el cultivo de la fresa. IICA. https://repositorio.iica.int/handle/11324/2932
Instituto Nacional de Estadística y Censos [INEC]. (2015). VI Censo Nacional Agropecuario: cultivos agrícolas, forestales y ornamentales. San José, Costa Rica. http://www.inec.go.cr/sites/default/files/documentos/agropecuario/publicaciones/reagropeccenagro2014-tii-007.pdf
Kanodia, L. y Das, S. (2009). A comparative study of analgesic property of whole plant and fruit extracts of Fragaria vesca in experimental animal models. Bangladesh Journal of Pharmacology, 4 (1), 35–38. https://doi.org/10.3329/bjp.v4i1.1049
Karlinska, E., Masny, A., Cieslak, M., Macierzynski, J., Pecio, Ł., Stochmal, A., y Kosmala, M. (2021). Ellagitannins in roots, leaves, and fruits of strawberry (Fragaria × ananassa Duch.) vary with developmental stage and cultivar. Scientia Horticulturae, 275, 109665. https://doi.org/10.1016/j.scienta.2020.109665
Kårlund, A., Hanhineva, K., Lehtonen, M., McDougall, G. J., Stewartc, D., y Karjalainena, R. O. (2017). Non-targeted metabolite profiling highlights the potential of strawberry leaves as a resource for specific bioactive compounds. Journal of the Science of Food and Agriculture, 97(7), 2182–2190. https://doi.org/10.1002/JSFA.8027
Kårlund, A., Salminen, J. P., Koskinen, P., Ahern, J. R., Karonen, M., Tiilikkala, K., y Karjalainen, R. O. (2014). Polyphenols in strawberry (Fragaria × ananassa) leaves induced by plant activators. Journal of Agricultural and Food Chemistry, 62(20), 4592–4600. https://doi.org/10.1021/jf405589f
Kim, H., Bassil, N., y Njuguna, W. (2011). Fragaria. En Kole, C. (Ed.), Wild Crop Relatives: Genomic and Breeding Resources. Temperate Fruits. Springer Berlin Heidelberg. https://link.springer.com/book/10.1007/978-3-642-16057-8
Kobi, H. B., Martins, M. C., Silva, P. I., Souza, J. L., Carneiro, J. C. S., Heleno, F. F., Queiroz, M. L., y Costa, N. M. B. (2018). Organic and conventional strawberries: Nutritional quality, antioxidant characteristics and pesticide residues. Fruits, 73 (1), 39–47. https://doi.org/10.17660/th2018/73.1.5
Kumari, S., Sankhyan, S., y Kumar, A. (2020). Yield and quality characters of different strawberry (Fragaria x ananassa duch.) cultivars growing under mid hill conditions of Himachal Pradesh. The Pharma Innovation Journal, 9 (6), 425–428. https://www.thepharmajournal.com
Lema-Rumińska, J., Kulus, D., Tymoszuk, A., Miler, N., Woźny, A., y Wenda-Piesik, A. (2021). Physiological, biochemical, and biometrical response of cultivated strawberry and wild strawberry in greenhouse gutter cultivation in the autumn-winter season in poland—preliminary study. Agronomy, 11 (8), 1633. https://doi.org/10.3390/agronomy11081633
Liston, A., Cronn, R., y Ashman, T. L. (2014). Fragaria: A genus with deep historical roots and ripe for evolutionary and ecological insights. American Journal of Botany, 101(10), 1686–1699. https://doi.org/10.3732/ajb.1400140
Liu, Z., Ma, H., Jung, S., Main, D., y Guo, L. (2020). Developmental Mechanisms of Fleshy Fruit Diversity in Rosaceae. Annual Review of Plant Biology, 71, 547–573. https://doi.org/10.1146/annurev-arplant-111119-021700
Marta, A. E., Camadro, E. L., Díaz-Ricci, J. C., y Castagnaro, A. P. (2004). Breeding barriers between the cultivated strawberry, Fragaria x ananassa, and related wild germplasm. Euphytica, 136(2), 139–150. https://doi.org/10.1023/B:EUPH.0000030665.95757.76
Massetani, F., Gangatharan, R., y Neri, D. (2011). Plant Architecture of Strawberry in Relation to Abiotic Stress, Nutrient Application and Type of Propagation System. En Husaini, A.M., y Mercado, J.A. (Eds.), Genes, Genomes and Genomics, 12–23. Global Science Books, UK.
Michalska, A., Carlen, C., Heritier, J., y Andlauer, W. (2017). Profiles of bioactive compounds in fruits and leaves of strawberry cultivars. Journal of Berry Research, 7 (2), 71–84. https://doi.org/10.3233/JBR-160146
Miller, K., Feucht, W., y Schmid, M. (2019). Bioactive compounds of strawberry and blueberry and their potential health effects based on human intervention studies: A brief overview. Nutrients, 11 (7), 1-12. https://doi.org/10.3390/nu11071510
Ministerio de Agricultura y Ganadería de Costa Rica [MAG]. (2014). Fragaria Spp. Rosaceae. MAG. http://www.mag.go.cr/bibioteca_virtual_ciencia/tec_fresa.pdf
Nunes, G., Teixeira, F., Schwarz, K., Camargo, C. K., De Resende, J. T. V., Dos Santos, E. F., Franco, B.C., y Novello, D. (2021). Influence of genetic variability on the quality of strawberry cultivars: Sensorial, physical-chemical and nutritional characterization. Acta Scientiarum - Agronomy, 43, e46862. https://doi.org/10.4025/actasciagron.v43i1.46862
Nunes, M. C. N., Brecht, J. K., Morais, A. M. M. B., y Sargent, S. A. (2005). Possible influences of water loss and polyphenol oxidase activity on anthocyanin content and discoloration in fresh ripe strawberry (cv. Oso Grande) during storage at 1°C. Journal of Food Science, 70 (1), S79–S84. https://doi.org/10.1111/j.1365-2621.2005.tb09069.x
Oguz, H. I., Zorlugenc, F. K., Zorlugenc, B., y Kafkas, N. E. (2017). A study on the variance of phytochemical properties in the fruit of some strawberry cultivars (Fragara ananassa L.) grown under environmental conditions in Adana region. Fresenius Environmental Bulletin, 26(6), 3963–3969. https://www.cabdirect.org/cabdirect/abstract/20173286393
Organización de las Naciones Unidas para la Alimentación y la Agricultura [FAO]. (2021). FAOStat. FAO. https://www.fao.org
Ornelas-Paz, J. D. J., Yahia, E. M., Ramírez-Bustamante, N., Pérez-Martínez, J. D., Escalante-Minakata, M. D. P., Ibarra-Junquera, V., Acosta-Muñoz, C., Guerrero-Prieto, V., y Ochoa-Reyes, E. (2013). Physical attributes and chemical composition of organic strawberry fruit (Fragaria x ananassa Duch, Cv. Albion) at six stages of ripening. Food Chemistry, 138 (1), 372–381. https://doi.org/10.1016/j.foodchem.2012.11.006
Palei, S., Das, A. K., y Rout, G. R. (2015). In vitro studies of strawberry - an important fruit crop: a review. Journal of Plant Science and Research, 31 (2), 115–131. https://www.proquest.com/scholarly-journals/vitro-studies-strawberry-important-fruit-crop/docview/1787816911/se-2?accountid=27651
Paparozzi, E. T., Meyer, G. E., Schlegel, V., Blankenship, E. E., Adams, S. A., Conley, M. E., Loseke, B. y Read, P. E. (2018). Strawberry cultivars vary in productivity, sugars and phytonutrient content when grown in a greenhouse during the winter. Scientia Horticulturae, 227, 1–9. https://doi.org/10.1016/j.scienta.2017.07.048
Pinheiro, D. F., de Resende, J. T. V., Constantino, L. V., Hata, F. T., Hata, N. N. Y., & Lustosa, S. B. C. (2021). Physical, biochemical, and sensory properties of strawberries grown in high-altitude tropical climate. Ciência e Agrotecnologia, 45, e008221. https://doi.org/10.1590/1413-7054202145008221
Prasad, R., Lisiecka, J., y Raj, K. (2022). Strawberry – More than a Popular Summer Fruit : A Mini-Review. Advances in Nutrition and Food Science, 2022 (2), 1–5. https://doi.org/10.37722/ANAFS.2022201
Programa de Investigación y Transferencia de Tecnología Agropecuaria-Fresa [PITTA-Fresa]. (2022). (PITTA-Fresa). Comunicación Personal. Costa Rica.
Programa Integral de Mercado Agropecuario [PIMA]. (2016). Análisis del consumo de frutas, hortalizas, pescado y mariscos en los hogares costarricenses. PIMA. Costa Rica. http://www.pima.go.cr
Rodríguez-Gutiérrez, G., Cubero Cardoso, J., Rubio-Senent, F., Serrano, A., Borja, R., Fernández-Bolaños, J., y Fermoso, F. G. (2019). Thermally-treated strawberry extrudate: A rich source of antioxidant phenols and sugars. Innovative Food Science and Emerging Technologies, 51, 186–193. https://doi.org/10.1016/j.ifset.2018.05.017
Roshan, R., Ahmed, S., y Mohtasheem ul Hassan, M. (2019). Fragaria nubicola ( Rosaceae ): A review of medicinal uses, phytochemistry and pharmacology. Journal of Pharmacognosy and Phytochemistry, 8 (4), 3390–3393. https://www.phytojournal.com/archives/2019/vol8issue4/PartBC/8-4-513-799.pdf
Ruan, J., Lee, Y. H., Hong, S. J., y Yeoung, Y. R. (2013). Sugar and organic acid contents of day-neutral and ever-bearing strawberry cultivars in high-elevation for summer and autumn fruit production in Korea. Horticulture Environment and Biotechnology, 54 (3), 214–222. https://doi.org/10.1007/s13580-013-0186-8
Ruíz Anchondo, T., Adriano Martínez, J., Carrillo Castillo, T., Parra Quezada, R. Á., Ojeda Barrios, D. L., y Hernández Rodríguez, A. (2018). Establecimiento in vitro de dos cultivares liberados de frutillas: fresa y frambuesa. Revista Mexicana de Ciencias Agrícolas, 9 (4), 799–812. https://doi.org/10.29312/remexca.v9i4.1397
Saroj, N. L., Singh, S., y Yadav, S. (2021). Strawberry : A wonder crop suitable for Hydroponics. Journal of Horticulture, 08 (2), 1–3. https://doi.org/10.35248/2376-0354.21.8.279
Sato, T., Ikeya, Y., Adachi, S. ichi, Yagasaki, K., Nihei, K. ichi, y Itoh, N. (2019). Extraction of strawberry leaves with supercritical carbon dioxide and entrainers: Antioxidant capacity, total phenolic content, and inhibitory effect on uric acid production of the extract. Food and Bioproducts Processing, 117, 160–169. https://doi.org/10.1016/j.fbp.2019.07.003
Serrano-Moral, A. (2015). Tratamiento de residuos y subproductos agroindustriales mediante co-digestión anaerobia. [Tesis de maestría]. Universidad de Córdoba, Colombia. https://helvia.uco.es/xmlui/handle/10396/12558
Shaheen, E. M. S. (2019). Protective effect of Fragaria induced diabetes in rats ananassa against streptozotocin-induced diabetes in rats. The Egyptian Journal of Experimental Biology (Zoology), 15 (1), 69–75. https://doi.org/10.5455/egysebz.20190415100613
Simpson, D. (2018). The Economic Importance of Strawberry Crops. En Hytönen, T., Graham, J. y Harrison R. (Eds.), The Genomes of Rosaceous Berries and Their Wild Relatives, 1–7. Springer International Publishing. https://doi.org/10.1007/978-3-319-76020-9_1
Singh, A., Singh, B. K., Deka, B. C., Sanwal, S. K., Patel, R. K., y Verma, M. R. (2011). The genetic variability, inheritance and inter-relationships of ascorbic acid, β-carotene, phenol and anthocyanin content in strawberry (Fragaria × ananassa Duch.). Scientia Horticulturae, 129 (1), 86–90. https://doi.org/10.1016/J.SCIENTA.2011.03.011
Skupien, K., Oszmianski, J., Kostrzewa-Nowak, D., y Tarasiuk, J. (2006). In vitro antileukaemic activity of extracts from berry plant leaves against sensitive and multidrug resistant HL60 cells. Cancer Letters, 236 (2), 282–291. https://doi.org/10.1016/j.canlet.2005.05.018
Staudt, G. (2009). Strawberry biogeography, genetics and systematics. Acta Horticulturae, 842, 71–84. https://doi.org/10.17660/ActaHortic.2009.842.1
Staudt, G. (1999). Systematics and Geographic Distribution of the American Strawberry Species: Taxonomic Studies in the Genus Fragaria (Rosaceae: Potentilleae) (81). University of California Press.
Toop, T. A., Ward, S., Oldfield, T., Hull, M., Kirby, M. E., y Theodorou, M. K. (2017). AgroCycle - Developing a circular economy in agriculture. Energy Procedia, 123, 76–80. https://doi.org/10.1016/j.egypro.2017.07.269
Tumbas, S. V., Gironés-Vilaplana, A., Djilas, S., Mena, P., Ćetković, G., Moreno, D. A., Čanadanović-Brunet, J., Vulić, J., Stajčić S., y Vinčić, M. (2015). Chemical composition and potential bioactivity of strawberry pomace. RSC Advances, 5(7), 5397–5405. https://doi.org/10.1039/c4ra14296a
Urün, I., Attar, S. H., Sönmez, D. A., Gündeşli, M. A., Ercişli, S., Kafkas, N. E., Bandić, L.M., y Duralija, B. (2021). Comparison of polyphenol, sugar, organic acid, volatile compounds, and antioxidant capacity of commercially grown strawberry cultivars in Turkey. Plants, 10, 1654. https://doi.org/10.3390/plants10081654
Van de Velde, F., Tarola, A. M., Güemes, D., y Pirovani, M. E. (2013). Bioactive compounds and antioxidant capacity of camarosa and selva strawberries (Fragaria x ananassa duch.). Foods, 2 (2), 120–131. https://doi.org/10.3390/foods2020120
Vargas, C. Y. A. y Peréz, P. L. I. (2018). Aprovechamiento de residuos agroindustriales en el mejoramiento de la calidad del ambiente. Revista Facultad de Ciencias Básicas, 14 (1), 59–72. https://doi.org/10.18359/rfcb.3108
Vázquez-González, M., Fernández-Prior, Á., Bermúdez, O. A., Rodríguez-Juan, E. M., Pérez-Rubio, A. G., Fernández-Bolaños, J., y Rodríguez-Gutiérrez, G. (2020). Utilization of strawberry and raspberry waste for the extraction of bioactive compounds by deep eutectic solvents. LWT - Food Science and Technology, 130, 109645. https://doi.org/10.1016/j.lwt.2020.109645
Villamil-Galindo, E., Van, de V. F. y Piagentini, A. M. (2020). Extracts from strawberry by-products rich in phenolic compounds reduce the activity of apple polyphenol oxidase. LWT - Food Science and Technology, 133, 110097. https://doi.org/10.1016/j.lwt.2020.110097
Villamil-Galindo, E., Van, de V. F. y Piagentini, A. M. (2021). Strawberry agro-industrial by-products as a source of bioactive compounds: effect of cultivar on the phenolic profile and the antioxidant capacity. Bioresources and Bioprocessing, 8 (61). https://doi.org/10.1186/s40643-021-00416-z
Warner, R., Wu, B. Sen, MacPherson, S., y Lefsrud, M. (2021). A Review of Strawberry Photobiology and Fruit Flavonoids in Controlled Environments. Frontiers in Plant Science, 12, 611893. https://doi.org/10.3389/fpls.2021.611893
Zhang, L., Ma, Q., y Zhou, Y. (2020). Strawberry leaf extract treatment alleviates cognitive impairment by activating Nrf2/HO-1 signaling in rats with streptozotocin-induced diabetes. Frontiers in Aging Neuroscience, 12, 201. https://doi.org/10.3389/fnagi.2020.00201
Zhu, Q., Nakagawa, T., Kishikawa, A., Ohnuki, K., y Shimizu, K. (2015). In vitro bioactivities and phytochemical profile of various parts of the strawberry (Fragaria × ananassa var. Amaou). Journal of Functional Foods, 13, 38–49. https://doi.org/10.1016/j.jff.2014.12.026
Ziemlewska, A., Nizioł-Lukaszewska, Z., Zagórska-Dziok, M., Bujak, T., Wójciak, M., y Sowa, I. (2022). Evaluation of cosmetic and dermatological properties of kombucha-fermented berry leaf extracts considered to be by-products. Molecules, 27 (7), 2345. https://doi.org/https://doi.org/10.3390/molecules27072345

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.


